Original Acrigen Publications
New Results
Discovery and engineering of AiEvo2, a novel Cas12a nuclease for human gene editing applications
Allison Sharrar, Luisa Arake de Tacca, Zuriah Meacham, Johanna Staples-Ager, Trevor Collingwood, David Rabuka, Michael Schelle
Published in The CRISPR Journal
Discovery and Characterization of Novel Type V Cas12f Nucleases with Diverse Protospacer Adjacent Motif Preferences
Allison Sharrar, Luisa Arake de Tacca, Trevor Collingwood, Zuriah Meacham, David Rabuka, Johanna Staples-Ager, Michael Schelle
New Results
Anti-CRISPR protein mediated degradation of Cas9 in human cells
Luisa Arake de Tacca, Joseph Bondy-Denomy, David Rabuka, Michael Schelle
Selected External Publications
Critical Anti-CRISPR Locus Repression by a Bi-functional Cas9 Inhibitor
Osuna BA, Karambelkar S, Mahendra C, Sarbach A, Johnson MC, Kilcher S, Bondy-Denomy J. Cell Host & Microbe 2020 28, 1–8.
Discovery of widespread Type I and Type V CRISPR-Cas inhibitors
*Marino ND, *Zhang JY, *Borges AL, Sousa AA, Leon LM, Rauch BJ, Walton RT, Berry JD, Joung JK, Kleinstiver BP, Bondy-Denomy J. Science 2018 Sep 06.
Bacteriophage cooperation suppresses CRISPR-Cas3 and Cas9 immunity
Borges AL, Zhang JY, Rollins MF, Osuna BA, Wiedenheft B, Bondy-Denomy J. Cell. 2018 Jul 19.
Inhibition of CRISPR-Cas9 with Bacteriophage Proteins
Rauch BJ, Silvis MR, Hultquist JF, Waters CS, McGregor MJ, Krogan NJ, Bondy-Denomy J. Cell 2017 Jan 12.
Multiple mechanisms for CRISPR–Cas inhibition by anti-CRISPR proteins
Bondy-Denomy J, Garcia B, Strum S, Du M, Rollins MF, Hidalgo-Reyes Y, Wiedenheft B, Maxwell K.L. & Alan R. Davidson A.R. Nature. 2015.
Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system
Bondy-Denomy J, Pawluk A, Maxwell KL, Davidson AR. Nature.